• More than 1,000 labs worldwide have purchased SB 203580 from LC Labs (either directly from us or from our many distributors, many of whom resell under their own labels).
• Important, highly specific inhibitor of the kinase known variously as p38, p40, CSBP, or RK. This kinase is a homolog of MAP kinase. Gallagher, T.F., et al. \"2,4,5-Triarylimidazole inhibitors of Il-1 biosynthesis.\" Bioorg. Med. Chem. Lett. 5: 1171-1176 (1995). Cuenda, A., et al. \"SB203580 is a specific inhibitor of MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.\" FEBS Lett.. 364: 229-233 (1995). Hazzalin, C.A., et al. \"Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli.\" Oncogene 15: 2321-2331 (1997).
• Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.

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