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MD Bioproducts/Citrullinated Collagen Type II Antibody (Clone ACC-4)/100 ug/1041004
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OverviewOverview:The citrullination of proteins is a post-translational modification where peptidyl arginine residues are converted to peptidyl citrulline by a family of enzymes called peptidyl arginine deiminases (PADs). Citrullination can be found in multiple tissue types and has been shown to occur in both human and mouse inflamed joints (1,2, 3). Proteins are susceptible to citrullination during inflammatory processes and an autoantibody response to citrullinated proteins is a hallmark of Rheumatoid Arthritis (RA). Antibodies against citrullinated proteins (ACPAs) can be found in 50-70% of all RA patients and have a high diagnostic value as a biomarker for detecting RA early (4,5). Current research is focused on understanding the detailed mechanisms causing direct inflammation of the joints and the self-perpetuating behavior of RA, via the recognition of post-translation modifications such as citrullination by T and B cells.
MD Biosciences成立于1991年,总部位于瑞士,在美国、加拿大和英国设有办事处。旗下MD Bioproducts部门主要产品涉及肿瘤、心血管、细胞培养、内分泌、炎症、代谢疾病、神经科学、疼痛、肾脏/肝脏功能等领域。产品包括抗体 (软骨蛋白聚糖、胶原蛋白、激素、神经药物)、细胞培养相关试剂 (胶原蛋白、细胞增殖检测、支原体PCR检测)、疾病诱导试剂 (关节炎诱导抗体混合、弗氏佐剂、胶原蛋白II等)、ELISA试剂盒、同型对照、天然蛋白以及重组蛋白。
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