Formulation: Sterile-filtered white lyophilized powder with no additives. Purified by proprietary chromatographic techniques.

Interleukin-1RA is a member of the Interleukin-1 (IL-1) cytokine family. It inhibits the activities of of IL-1 alpha and IL-1 beta and modulates a variety of IL- 1-related immune and inflammatory responses. A polymorphism of this gene is reported to be associated with an increased risk of osteoporotic fractures and gastric cancer.

Recombinant human IL-1RA produced in E. coli is a non-glycosylated N- terminal methionyl form of the naturally- occurring polypeptide containing 153 amino acids with a molecular weight of 17kDa.

Catalog Number

Size

40101P-20

20ug

40101P-100

100ug

40101P-1000

1000ug

Catalog Number

Size

40101P-20

20ug

40101P-100

100ug

40101P-1000

1000ug

Source: Escherichia coli

Purity: Greater than 98% as determined by SDS-PAGE and RP- HPLC.

Accession number: P18510.1

Amino acid sequence: The sequence of the first five N-terminal amino acids is Met-Arg-Pro-Ser-Gly.

ED50 by dose-dependent inhibition of IL-1 stimulation of D10S cells is 0.5ng/ml which corresponds to a Specific Activity of 2,000,000IU/mg.

Reconstitute in sterile distilled H2O to not less than 100ug/ml which can be further diluted in other aqueous solutions.

STORAGE AND STABILITY

Store dessicated below -18oC. After reconstitution, store at 4oC for 2-7 days and below -18oC for future use. For long term storage of the reconstituted product, addition of 0.1% human serum albumin or bovine serum albumin is recommended. Avoid multiple freeze- thaw cycles.

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.