Adipogen/Genistein/AG-CN2-0427-M050/50 mg
More Information Product Details
Synonyms NSC 36586; Baichanin A; Differenol A; 4,5,7-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
Product Type Chemical |
Properties
Formula C15H10O5 |
MW 270.2 |
Merck Index 14: 4391 |
CAS 446-72-0 |
RTECS NR2392000 |
Source/Host Chemicals Synthetic. |
Purity Chemicals ≥99% |
Appearance White to off-white solid. |
Solubility Soluble in DMSO; slightly soluble in ethanol. Insoluble in water. |
InChi Key TZBJGXHYKVUXJN-UHFFFAOYSA-N |
Shipping and Handling
Shipping AMBIENT |
Short Term Storage +4°C |
Long Term Storage -20°C |
Handling Advice Keep cool and dry.Protect from light. |
Use/Stability Stable for at least 2 years after receipt when stored at -20°C. |
Documents
MSDS Download PDF |
Product Specification Sheet
Datasheet Download PDF |
- Cell-permeable, reversible, substrate competitive tyrosine kinase inhibitor (including EGFR phosphorylation), implicated in almost all cell growth and proliferation signal cascades [1].
- Inhibitor of mammalian DNA topoisomerase II [2].
- Anticancer agent, inducing cell cycle arrest and apoptosis [3].
- Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis [12].
- Binds estrogen receptor β. Can increase the rate of growth of some ER expressing breast cancers [4, 10].
- Potent α-glucosidase inhibitor [5].
- Anthelmintic [6].
- Anti-diabetic. Activates nuclear receptors, oestrogen receptors and peroxisome proliferator-activated receptors (all PPAR isoforms) and it inhibits various enzyme activities [7, 8, 14].
- Inhibitor of GLUT4-mediated glucose uptake in 3T3-L1 adipocytes [9].
- Stimulator of autophagy vacuolization [12].
- Antioxidant [13].
- TRAIL sensitizer [15].
- Acts as an agonist at the GPR30 receptor [16].
- MALT1 inhibitor [17]
- DNA methyltransferase inhibitor [18].
- Genistein exhibits synergistic antibacterial effects on MRSA [19].
Product References
Genistein, a specific inhibitor of tyrosine-specific protein kinases: T. Akiyama, et al.; J. Biol. Chem. 262, 5592 (1987)Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II: J. Markovits, et al.; Cancer Res. 49, 5111 (1989)Genistein inhibition of the growth of human breast cancer cells: independence from estrogen receptors and the multi-drug resistance gene: G. Peterson & S. Barnes; BBRC 179, 661 (1991)Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta: G.G. Kuiper, et al.; Endocrinology 139, 4252 (1998)Genistein, a soy isoflavone, is a potent alpha-glucosidase inhibitor: DS. Lee & SH. Lee; FEBS Lett. 501, 84 (2001)Anthelmintic efficacy of Flemingia vestita: genistein-induced effect on the activity of nitric oxide synthase and nitric oxide in the trematode parasite, Fasciolopsis buski: P.K. Kar, et al.; Parasitol. Int. 51, 249 (2002)Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese Zucker rats and murine RAW 264.7 cells: O. Mezei, et al.; J. Nutr. 133, 1238 (2003)Peroxisome proliferator-activated receptor gamma (PPARgamma ) as a molecular target for the soy phytoestrogen genistein: Z.C. Dang, et al.; J. Biol. Chem. 278, 962 (2003)Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes: M. Bazuine, et al.; BBRC 326, 511 (2005)Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations Y.H. Ju, et al.; Carcinogenesis 27, 1292 (2006)Phytochemical genistein in the regulation of vascular function: new insights: H. Si & D. Liu; Curr. Med. Chem. 14, 2581 (2007)Diet, autophagy, and cancer: a review: K. Singletary & J. Milner; Cancer Epidemiol. Biomarkers Prev. 17, 1596 (2008) (Review)Comparison of flavonoids and isoflavonoids as antioxidants: RM. Han, et al.; J. Agric. Food Chem. 57, 3780 (2009)Dose-dependent effects of soy phyto-oestrogen genistein on adipocytes: mechanisms of action: Z.C. Dang; Obes. Rev. 10, 342 (2009) (Review)Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis: D. Finlay, et al.; PLoS One 5, e13375 (2010)Genistein regulates the IL-1 beta induced activation of MAPKs in human periodontal ligament cells through G protein-coupled receptor 30: L.J. Luo, et al.; Arch. Biochem. Biophys. 522, 9 (2012)MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo: L. Fontan, et al.; Cancer Cell 22, 812 (2012)DNA methyltransferase-1 inhibitors as epigenetic therapy for cancer: V. Singh, et al.; Curr. Cancer Drug Targets 13, 379 (2013)Flavonoids from Sophora moorcroftiana and their synergistic antibacterial effects on MRSA: SY. Wang, et al.; Phytother. Res. 28, 1071 (2014)