Recombinant Human Cardiac Troponin I (TnI)
Catalog Number
Size
24001P-10
10ug
24001P-50
50ug
24001P-1000
1000ug
Catalog Number
Size
24001P-10
10ug
24001P-50
50ug
24001P-1000
1000ug
ORDERING INFORMATION
Formulation: Sterile-filtered solution in 50mM Tris, pH 8.0 and 6M urea.
Purified by proprietary chromatographic techniques.
BACKGROUNDTroponin I (TnI) troponin T (TnT) and troponin C (TnC) form the troponin complex of thin filaments of striated muscle. TnI acts as the inhibitory subunit by blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily consists of 3 genes: TnI- skeletal-fast-twitch, TnI-skeletal-slow- twitch, and TnI-cardiac. The TNNI3 gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissue. Mutations in the TNNI3 gene cause familial hypertrophic cardiomyopathy type 7 and familial restrictive cardiomyopathy.
DESCRIPTIONRecombinant Human TnI produced in E. coli is a single, non-glycosylated polypeptide chain containing 165 amino acids with a molecular weight of 24 kDa.
SPECIFICATION SUMMARYSource: Escherichia coli
Purity: Greater than 98% as determined by SDS- PAGE and RP- HPLC.
Accession number: P19429
STORAGE AND STABILITYAlthough stable at 4oC for 1 week, product is best stored at or below -20oC. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long-term storage.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.
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San Diego, CA 92127
Toll Free 800.929.2114
Phone 858.675.2405
Fax 858.592.1509
info@qedbio.com
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