More Information Product Details Synonyms Product Type Properties Source/Host Sequence Crossreactivity Specificity MW Purity Endotoxin Content Concentration Reconstitution Formulation Other Product Data Shipping and Handling Shipping Short Term Storage Long Term Storage Handling Advice Use/Stability Documents MSDS Product Specification Sheet Datasheet

4-1BBL; TNFSF9

Protein

HEK 293 cells

The receptor-binding domain of human CD137L (aa 85-254) is fused at the N-terminus to the Fc portion of human IgG1.

Human

Binds to human CD137 receptor.

~46kDa (SDS-PAGE)

≥90% (SDS-PAGE)

0.1mg/ml after reconstitution.

Reconstitute with 100μl sterile water.

Lyophilized. Contains PBS.

Uniprot link P41273: CD137L (human)

BLUE ICE

+4°C

-20°C

After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.PBS containing at least 0.1% BSA should be used for further dilutions.

Stable for at least 6 months after receipt when stored at -20°C.

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The CD137 ligand (CD137L; 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes and in T and B cell co-stimulation and modulation of the immune response.