Adipogen/1,5-Isoquinolinediol/AG-CR1-0024-M100/100 mg-蚂蚁淘生物

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5-Hydroxy-1(2H)-isoquinolinone; 1,5-Dihydroxyisoquinoline

Chemical

C₉H₇NO₂

161.2

5154-02-9

≥98% (NMR)

White to off-white solid.

Soluble in DMSO or methanol; insoluble in water.

LFUJIPVWTMGYDG-UHFFFAOYSA-N

AMBIENT

+4°C

Protect from light.

Stable for at least 2 years after receipt when stored at +4°C.

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PARP-1 inhibitor [1].
Neuroprotectant [2].
Blocks nitric oxide-induced neuronal toxicity [2].
Potent iNOS (inducible nitric oxide synthase/NOS II) inhibitor [3].
Stimulates homologous recombination [4].

Product References

Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase: M. Banasik, et al.; J. Biol. Chem. 267, 1569 (1992)

Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity: J. Zhang, et al.; Science 263, 687 (1994)

Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP: R. Olszanecki, et al.; J. Physiol. Pharmacol. 57, 109 (2006)

1,5-isoquinolinediol increases the frequency of gene targeting by homologous recombination in mouse fibroblasts: A. Semionov, et al.; Biochem. Cell Biol. 81, 17 (2003)

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