Adipogen/Ingenol-3-angelate/AG-CN2-0012-M001/1 mg
More Information Product Details
Synonyms | PEP005; I3A; Ingenol mebutate |
Product Type | Chemical |
Properties
Formula | C25H34O6 |
MW | 430.5 |
CAS | 75567-37-2 |
Source/Host Chemicals | Semi-synthetic. |
Purity Chemicals | ≥97% (HPLC) |
Appearance | White to off-white solid. |
Solubility | Soluble in 100% ethanol, DMSO or dichloromethane. |
Identity | Determined by 1H-NMR. |
Other Product Data | The starting material ingenol was isolated from Euphorbia latyris. |
InChi Key | VDJHFHXMUKFKET-XCHJBCONSA-N |
Shipping and Handling
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents
MSDS ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Product Specification Sheet
Datasheet | Download PDF |
- Specific protein kinase C (PKC) activator [1].
- Selective activator of PKC isoforms, like PKCθ in T cells [1, 5, 8].
- Antiproliferative and proapoptotic (necrotic) [2, 3, 5].
- Immunostimulant [6].
- Chemotherapeutic [4, 6].
- Anticancer compound [2, 3, 5].
- Efficacious agent against actinic kerastosis [7].
- Antileukemic [8].
Product References
Characterization of the interaction of ingenol 3-angelate with protein kinase C: N. Kedei, et al.; Cancer Res. 64, 3243 (2004)Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells: S.K. Gillespie, et al.; Mol. Cancer Ther. 3, 1651 (2004)PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC: P. Hampson, et al.; Blood 106, 1362 (2005)Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate: J.M. Challacombe, et al.; J. Immunol. 177, 8123 (2006)The anti-tumor agent, ingenol-3-angelate (PEP005), promotes the recruitment of cytotoxic neutrophils by activation of vascular endothelial cells in a PKC-delta dependent manner: P. Hampson, et al.; Cancer Immunol. Immunother. 57, 1241 (2008)Immunostimulatory cancer chemotherapy using local ingenol-3-angelate and synergy with immunotherapies: T.T. Le, et al.; Vaccine 27, 3053 (2009)Randomized, double-blind, double-dummy, vehicle-controlled study of ingenol mebutate gel 0.025% and 0.05% for actinic keratosis: L. Anderson, et al.; J. Am. Acad. Dermatol. 60, 934 (2009)Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta: W.Y. Lee, et al.; JBC 285, 23889 (2010)
