Adipogen/6-Aminophenanthridine/AG-MR-C0029-M001/1 mg
More Information Product Details
Synonyms | 6AP |
Product Type | Chemical |
Properties
Formula | C13H10N2 |
MW | 194.2 |
CAS | 832-68-8 |
Purity Chemicals | ≥97% (HPLC) |
Appearance | Beige solid. |
Solubility | Soluble in DMSO or ethanol. |
Reconstitution | Stock solutions can be made up to 10mM in DMSO. |
Identity | Determined by 1H-NMR. |
InChi Key | FVCXJXKLDUJOFA-UHFFFAOYSA-N |
Shipping and Handling
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | After reconstitution, prepare aliquots and store at -20°C. |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents
MSDS ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Product Specification Sheet
Datasheet | Download PDF |
- Antiprion agent.
- Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome.
- Inhibitor of protein aggregation.
Product References
An expeditious synthesis of 6-aminophenanthridines: F. Gug, et al.; THL 46, 3725 (2005)Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs: D. Tribouillard-Tanvier, et al.; PLoS One 3, e2174 (2008)Tools for the study of ribosome-borne protein folding activity: C. Voisset, et al.; Biotechnol. J. 3, 1033 (2008)Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding: S.D. Reis, et al.; Biochimie 93, 1047 (2011)Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy: N. Barbezier, et al.; EMBO Mol. Med. 3, 35 (2011)The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition: Y. Pang, et al.; J. Biol. Chem. 288, 19081 (2013)
