Adipogen/6BIO/AG-CR1-0056-M005/5 mg
More Information Product Details
Synonyms | (2’Z,3’E)-6-Bromoindirubin-3’-oxime |
Product Type | Chemical |
Properties
Formula | C16H10BrN3O2 |
MW | 356.2 |
CAS | 667463-62-9 |
Purity Chemicals | ≥98% (NMR) |
Appearance | Dark red solid. |
Solubility | Soluble in DMSO. |
Identity | Determined by 1H-NMR. |
InChi Key | DDLZLOKCJHBUHD-WAVHTBQISA-N |
Shipping and Handling
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Protect from light. |
Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
Documents
MSDS ![](\"https://www.ebiomall.com/images/adipogen/download.png\") Download PDF |
Product Specification Sheet
Datasheet | Download PDF |
- Phosphoinositide-dependent kinase 1 (PDK1) inhibitor.
- Potent, reversible and ATP-competitive glycogen synthase kinase-3α/β (GSK-3α/β) inhibitor.
- JAK/STAT3 signaling inhibitor.
- Apoptosis inducer.
- Potent antiproliferative agent in malignant lymphoid cell.
- Antimetastatic agent.
- Potent chemosensitizing agent fighting TRAIL resistant cancer cells.
Product References
GSK-3-selective inhibitors derived from Tyrian purple indirubins: L. Meijer, et al.; Chem. Biol. 10, 1255 (2003)Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases: P. Polychronopoulos, et al.; J. Med. Chem. 47, 935 (2004)The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes: A.S. Tseng, et al.; Chem. Biol. 13, 957 (2006)7-Bromoindirubin-3-oxime induces caspase-independent cell death: J. Ribas, et al.; Oncogene 25, 6304 (2006)Inverse in silico screening for identification of kinase inhibitor targets: S. Zahler, et al.; Chem. Biol. 14, 1207 (2007)An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins: V. Myrianthopoulos, et al.; J. Med. Chem. 50, 4027 (2007)Indirubin derivatives inhibit malignant lymphoid cell proliferation: A. Chebel, et al.; Leuk. Lymphoma 50, 2049 (2009)6-Bromoindirubin-3-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells: L. Liu, et al.; Cancer Res. 71, 3972 (2011)Indirubin derivative 6BIO suppresses metastasis: S. Braig, et al.; Cancer Res. 73, 6004 (2013)The pleiotropic profile of the indirubin derivative 6BIO overcomes TRAIL resistance in cancer: S. Braig, et al.; Biochem. Pharmacol. 91, 157 (2014)
