Adipogen/LAG-3 (mouse):Fc (mouse) (rec.)/AG-40B-0039-C050/50 µg-蚂蚁淘生物

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Lymphocyte Activation Gene-3; FDC Protein; CD223

Protein

CHO cells

The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH₂-CH₃).

HumanMouse

Binds to human and mouse MHC class II.

Induces maturation of mouse dendritic cells in vitro. Induces CD4 and CD8 antigen-specific T cells responses when coinjected s.c. in mice, together with the antigen.

~180kDa (SPS-PAGE, nonreducing), ~80kDa (SPS-PAGE, reducing)

≥95% (SDS-PAGE)

0.5 mg/ml

Liquid. In PBS.

Application: Flow Cytometry: Detection of MHC class II molecules in combination with fluorescently labeled antibodies to IgG2a. Uni-Prot link Q61790: LAG-3 (mouse)

DRY ICE

-20°C

After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.PBS containing at least 0.1% BSA should be used for further dilutions.

Stable for at least 6 months after receipt when stored at -20°C.

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Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

Product References

LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice: P. Cappello, et al.; Cancer Res. 63, 2518 (2003)

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