Fitzgerald/STAT6 antibody/10R-2207/100 ul
OVERVIEW:
Synonyms | Monoclonal STAT6 antibody, Anti-STAT6 antibody, Signal transducer and activator of transcription 6 antibody, STAT6B antibody, STAT6C antibody, D12S1644 antibody, IL-4-STAT antibody, STAT6, STAT 6, STAT-6, STAT 6 antibody, STAT-6 antibody |
Cross Reactivity | Human, Mouse, Rat, Monkey |
Applications | ELISA, IF, WB |
Immunogen | STAT6 antibody was raised in Mouse using a purified recombinant fragment of human STAT6 expressed in E. coli as the immunogen. |
SPECIFICATIONS:
Host | Mouse |
Clone | 7D3 |
Isotype | IgG1 |
Form & Buffer | Supplied as a liquid in ascitic fluid containing 0.03% sodium azide. |
Concentration | 1.0 mg/ml |
STORAGE & SAFETY:
Storage | Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Usage Assay Information:
Usage Recommendations | ELISA: 1:10,000, IF: 1:200-1:1000, WB: 1:500-1:2000 |
GENERAL INFORMATION:
Biological Significance | STAT6 protein is a transcription factor activated by cytokines, particularly interleukin 4 and IL 13. STAT6 was found to be deficient in IL 4 mediated functions including Th2 helper T cell differentiation, expression of cell surface markers, T cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL 4 mediated proliferation. STAT6 mRNA has been detected in peripheral bloodlymphocytes, colon, intestine, ovary, prostate,thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response. |
