Fitzgerald/CTNNB1 antibody/10R-3761/100 ul
OVERVIEW:
Synonyms | Monoclonal CTNNB1 antibody, Anti-CTNNB1 antibody, Catenin beta 1 antibody, CTNNB antibody, DKFZp686D02253 antibody, Beta catenin antibody, CTNNB1, CTNNB 1, CTNNB-1, CTNNB 1 antibody, CTNNB-1 antibody |
Cross Reactivity | Human, Dog, Rat, Monkey |
Applications | FC, IHC, WB |
Immunogen | CTNNB1 antibody was raised in mouse using a full length recombinant protein of human CTNNB1 (NP_001895) produced in HEK293T cells, as the immunogen. |
SPECIFICATIONS:
Host | Mouse |
Clone | 9H2 |
Isotype | IgG2b |
Method of Purification | CTNNB1 antibody was purified by affinity chromatography. |
Form & Buffer | Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 500 ug-1 mg/ml |
STORAGE & SAFETY:
Storage | Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Usage Assay Information:
Usage Recommendations | FC: 1:100, IHC: 1:150, WB: 1:1000-2000 |
GENERAL INFORMATION:
Biological Significance | CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. |
