Fitzgerald/MUC1 antibody/10R-8091/100 ug
OVERVIEW:
Synonyms | Monoclonal MUC1 antibody, Anti-MUC1 antibody, MUC-1 antibody, MUC 1 antibody, Mucin-1 antibody, CD227 antibody, MUC1 |
Specificity | React with a peptide epitope in the repeat region of MUC-1 |
Cross Reactivity | Human |
Applications | ELISA, FC, IF, IHC-F, IP, WB |
Immunogen | MUC1 antibody was raised in Mouse using human milk-fat globule membranes (HMFGM) as the immunogen. |
SPECIFICATIONS:
Host | Mouse |
Clone | 139H2 |
Isotype | IgG1 |
Form & Buffer | Supplied in PBS containing 0.09% sodium azide |
Usage Assay Information:
Usage Recommendations | Optimal dilution should be determined by titration |
GENERAL INFORMATION:
Biological Significance | Mucins are heavily glycosylated proteins which constitute the major components of mucus covering the surface of epithelial tissues. Nine distinct epithelial mucin genes (Muc-1, 2, 3, 4, 5AC, 5B, 6, 7 and 8) have been identified. Various immunohistochemical and in situ hybridization studies have reported that these mucins are differentially expressed in epithelia with cell-type specificity. In gastric cancer, alterations in mucin polypeptide expression have been reported, including the loss of expression of Muc-5AC glycoprotein, increased mucin heterogeneity, glycosylation changes and the expression of simple mucin-type carbohydrates. |
