首页 > NSJ Bio > NSJ Bio/OCT-2 Antibody / POU2F2 [clone OCT2/2137] (V3913)/100 ug/V3913SAF-100UG

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NSJ Bio/OCT-2 Antibody / POU2F2 [clone OCT2/2137] (V3913)/100 ug/V3913SAF-100UG

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V3913SAF-100UG

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DescriptionOct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. Oct-2 expression can be used as a marker of B-cell lineage and differentiation. Germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells show high level expression of Oct-2. Additionally, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma display increased expression of Oct-2. Several studies of Oct-2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines have high levels of expression. In spite of scanty evidence for Oct-2 expression in T cells, it is believed that this factor participates in transcriptional regulation during T-cell activation. Application NotesOptimal dilution of the OCT-2 antibody should be determined by the researcher.ImmunogenA portion of amino acids 112-297 from the human protein was used as the immunogen for the OCT-2 antibody.StorageStore the OCT-2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).Related Products1. View all OCT-2 antibodies2. View all human protein microarray validated antibodies

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