DescriptionTelomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3"-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5"-TTAGGG-3". The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. [UniProt]Application NotesTitration of the TERT antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenA portion of amino acids 1104-1132 from the human protein was used as the immunogen for this TERT antibody.StorageAliquot the TERT antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles. Related Products1. View all TERT antibodies

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