DescriptionRecognizes a single protein of 40kDa, identified as CD305/LAIR1. It is an inhibitory receptor, expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells.This MAb is expressed on CD34 positive hematopoietic progenitors. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. This MAb is identical to LAIR-1, based on the fact that it not only precipitated a protein of 40kDa but it also binds specifically to LAIR-1 cDNA transfected COS7 cells as well as recognizes LAIR-1 fusion protein in ELISA. LAIR-1 expresses on hematopoietic progenitor, implicating its role in the regulation of hematopoiesis at early stage.Application NotesOptimal dilution of the LAIR-1 antibody should be determined by the researcher.1. The 9.1C3 mAb has been shown to inhibits NK & ALK cell-mediated cytolysis, inhibit TNF-alpha secretion of NK cells, and induce colony formation of human bone marrow cells.ImmunogenHuman lymphocytes and large granular lymphocytes (LGL) were used as the immunogen for the LAIR-1 antibody.StorageStore the LAIR-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide). Citations (11)Related Products1. View all LAIR-1 antibodies

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