首页 > NSJ Bio > NSJ Bio/Rad21 Antibody [clone CBH-18] (RQ4748)/100 ul/RQ4748

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NSJ Bio/Rad21 Antibody [clone CBH-18] (RQ4748)/100 ul/RQ4748

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RQ4748

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Description"Double-strand-break repair protein rad21 homolog" is a cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. [UniProt]Application NotesOptimal dilution of the Rad21 antibody should be determined by the researcher.ImmunogenA synthetic peptide specific to human Rad21 was used as the immunogen for the Rad21 antibody.StorageStore the Rad21 antibody at -20oC. Related Products1. View all Rad21 antibodies

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