首页 > NSJ Bio > NSJ Bio/ALK Antibody / Anaplastic Lymphoma Kinase [clone ALK/1504] (V3817)/20 ug/V3817-20UG

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NSJ Bio/ALK Antibody / Anaplastic Lymphoma Kinase [clone ALK/1504] (V3817)/20 ug/V3817-20UG

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V3817-20UG

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NSJ Bio

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DescriptionThe wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene,Â NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control.Application NotesThe stated application concentrations are suggested starting amounts.Titration of the ALK antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenA portion of amino acids 200-335 from the human protein was used as the immunogen for this ALK antibody.StorageStore the recombinant ALK antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).Related Products1. View all ALK antibodies

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