首页 > NSJ Bio > NSJ Bio/Recombinant TG Antibody / Thyroglobulin [clone rTGB24] (V3628)/20 ug/V3628-20UG

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NSJ Bio/Recombinant TG Antibody / Thyroglobulin [clone rTGB24] (V3628)/20 ug/V3628-20UG

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V3628-20UG

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NSJ Bio

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DescriptionThyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.Application NotesOptimal dilution of the recombinant TG antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.ImmunogenHuman thyroid follicular cells were used as the immunogen for the recombinant TG antibody.StorageStore the recombinant TG antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).Related Products1. View all TG antibodies2. View all recombinant antibodies

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