首页 > NSJ Bio > NSJ Bio/Thymidylate Synthase Antibody [clone ADAA-20] (RQ5083)/100 ul/RQ5083

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NSJ Bio/Thymidylate Synthase Antibody [clone ADAA-20] (RQ5083)/100 ul/RQ5083

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RQ5083

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DescriptionThymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1, vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [RefSeq]Application NotesOptimal dilution of the Thymidylate Synthase antibody should be determined by the researcher.ImmunogenA synthetic peptide specific to human Thymidylate Synthase / TYMS was used as the immunogen for the Thymidylate Synthase antibody.StorageStore the Thymidylate Synthase antibody at -20oC. Related Products1. View all Thymidylate Synthase antibodies

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