产品说明
DescriptionATP-Binding Cassette, Subfamily A, Member 4, also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. It is a member of the ATP-binding cassette transporter gene sub-family A(ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, Allikmets et al.(1997) mapped the gene to 1p21-p13. Allikmets et al.(1997) localized transcripts exclusively within photoreceptor cells, indicating that ABCA4 mediates the transport of an essential molecule(or ion) either into or out of photoreceptor cells. Molday et al.(2000) showed by immunofluorescence microscopy and Western blot analysis that ABCA4 is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises directly from ABCA4-mediated foveal cone degeneration.Application NotesThe stated application concentrations are suggested starting amounts.Titration of the ABCA4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenAn amino acid sequence from the C-terminus of human ATP-Binding Cassette, Subfamily A, Member 4 (TLLVQRHFFLSQWI) was used as the immunogen for this ABCA4 antibody.StorageAfter reconstitution, the ABCA4 antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing.Related Products1. View all ATP-Binding Cassette/ABC antibodies2. View all ABCA4 antibodies
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