首页 > NSJ Bio > NSJ Bio/ABCB11 Antibody (F49436)/0.4 ml/F49436-0.4ML

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NSJ Bio/ABCB11 Antibody (F49436)/0.4 ml/F49436-0.4ML

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F49436-0.4ML

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NSJ Bio

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DescriptionABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.Application NotesTitration of the ABCB11 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenA portion of amino acids 1038-1067 from the human protein was used as the immunogen for this ABCB11 antibody.StorageAliquot the ABCB11 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles. Related Products1. View all ABCB11 antibodies

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