首页 > NSJ Bio > NSJ Bio/ABCG1 Antibody (R30967)/100 ug/R30967

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NSJ Bio/ABCG1 Antibody (R30967)/100 ug/R30967

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R30967

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DescriptionABCG1 (ATP-binding cassette, subfamily G, member 1) also known as ABC8, is a protein that in humans is encoded by the ABCG1 gene. ABCG1 is a regulator of macrophage cholesterol and phospholipid transport. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. The gene is mapped on 21q22.3. This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. ABCG1 is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. Inhibition of ABCG1 protein expression using an antisense strategy resulted in reduced HDL3-dependent efflux of cholesterol and choline-phospholipids. In macrophages, silencing of GPS2 by RNA interference reducedABCG1expression and diminished ABCG1-mediated cholesterol efflux.Application NotesThe stated application concentrations are suggested starting amounts.Titration of the ABCG1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenAn amino acid sequence from the C-terminus of human ABCG1 (ETCHFQKSEAILRELDVENAK) was used as the immunogen for this ABCG1 antibody (100% homologous in human, mouse and rat).StorageAfter reconstitution, the ABCG1 antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing.Related Products1. View all ATP-Binding Cassette/ABC antibodies2. View all ABCG1 antibodies

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