首页 > NSJ Bio > NSJ Bio/ACTH Antibody / CLIP [clone CLIP/1449] (V3213)/100 ug/V3213SAF-100UG

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NSJ Bio/ACTH Antibody / CLIP [clone CLIP/1449] (V3213)/100 ug/V3213SAF-100UG

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V3213SAF-100UG

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NSJ Bio

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DescriptionACTH (or Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This mAb is specific to CLIP (aa 25-39) and does not react with Synacthen (aa 1-24). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. Application NotesThe concentration stated for each application is a general starting point.Variations in protocols, secondaries and substrates may require the ACTH antibody to be titered up or down for optimal performance.ImmunogenAmino acids 25-39 (NGAEDESAEAFPLEF) of Adrenocorticotropic hormone (CLIP sequence) were used as the immunogen for this ACTH antibody.StorageStore the ACTH antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide). References (1) Related Products1. View all ACTH antibodies

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