DescriptionRAC-gamma serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT3 gene. This gene is mapped to 1q43-q44. The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor(PDGF), insulin, and insulin-like growth factor 1(IGF1). AKT3 plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. This gene is required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands.Application NotesThe stated application concentrations are suggested starting amounts.Titration of the AKT3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenAmino acids 122-136 (TSQIDNIGEEEMDAS) were used as the immunogen for this AKT3 antibody (100% homologous in human, mouse and rat).StorageAfter reconstitution, the AKT3 antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing. Related Products1. View all AKT3 antibodies

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