首页 > NSJ Bio > NSJ Bio/Alpha A Crystallin Antibody / CRYAA (R32408)/100 ug/R32408

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NSJ Bio/Alpha A Crystallin Antibody / CRYAA (R32408)/100 ug/R32408

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DescriptionAlpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene. Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).Application NotesOptimal dilution of the Alpha A Crystallin antibody should be determined by the researcher.ImmunogenAmino acids M1-S173 from the human protein were used as the immunogen for the Alpha A Crystallin antibody.StorageAfter reconstitution, the Alpha A Crystallin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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