首页 > NSJ Bio > NSJ Bio/Anti-Caspase-8 Antibody (large subunit) (R30365)/100 ug/R30365

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NSJ Bio/Anti-Caspase-8 Antibody (large subunit) (R30365)/100 ug/R30365

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R30365

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NSJ Bio

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4000-520-616

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DescriptionMost upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases including CASP3/4/6/7/9/10. [UniProt]Application NotesThe stated application concentrations are suggested starting points.Titration of the anti-Caspase-8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenAmino acids 240-259 (DKVYQMKSKPRGYCLIINNH-human) were used as the immunogen for this anti-Caspase-8 antibody.This sequence is from the large subunit.StorageAfter reconstitution, the anti-Caspase-8 antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing. Related Products1. View all Caspase-8 antibodies

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