首页 > NSJ Bio > NSJ Bio/Anti-CD45 Antibody (R30674)/100 ug/R30674

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NSJ Bio/Anti-CD45 Antibody (R30674)/100 ug/R30674

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R30674

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DescriptionCluster of Differentiation 45, also known as PTPRC, is an enzyme that, in humans, is encoded by the PTPRC gene. It is a member of the protein tyrosine phosphatase(PTP) family. CD45 is a major high molecular mass leukocyte cell surface molecule which is also an integral membrane protein tyrosine phosphatase. Targeted disruption of the gene leads to enhanced cytokine and interferon receptor-mediated activation of JAKs and STAT proteins. In vitro, CD45 directly dephosphorylates and binds to JAKs. Functionally, it negatively regulates interleukin-3-mediated cellular proliferation, erythropoietin-dependent hematopoiesis, and antiviral responses in vitro and in vivo. It has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse(IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be finetuned by varying usage of the heavily Oglycosylated spliced regions and sialylation of Nlinked carbohydrates.Application NotesThe stated application concentrations are suggested starting amounts.Titration of the anti-CD45 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenAmino acids 1209-1227 (MVSTFEQYQFLYDVIASTY-human) were used as the immunogen for this anti-CD45 antibody.StorageAfter reconstitution, the anti-CD45 antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing.Related Products1. View all CD45 antibodies2. View all CD45 antibodies

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