首页 > NSJ Bio > NSJ Bio/ATF4 Antibody (F42021)/0.08 ml/F42021-0.08ML

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NSJ Bio/ATF4 Antibody (F42021)/0.08 ml/F42021-0.08ML

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F42021-0.08ML

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NSJ Bio

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DescriptionATF4 is a transcriptional activator that binds the cAMP response element (CRE) (consensus: 5"-GTGACGT[AC][AG]-3"), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. [UniProt]Application NotesTitration of the ATF4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenA portion of amino acids 171-198 from the human protein was used as the immunogen for this ATF4 antibody.StorageAliquot the ATF4 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles. Related Products1. View all ATF4 antibodies

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