首页 > NSJ Bio > NSJ Bio/Beta Catenin Antibody [clone CTNNB1/1507] (V3242)/100 ug/V3242-100UG

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NSJ Bio/Beta Catenin Antibody [clone CTNNB1/1507] (V3242)/100 ug/V3242-100UG

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V3242-100UG

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NSJ Bio

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DescriptionBeta-Catenin associates with the cytoplasmic portion of E-Cadherin, which is necessary for the function of E-Cadherin as an adhesion molecule. In normal tissues, beta-Catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-Catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immunostaining of beta-Catenin and E-Cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.Application NotesOptimal dilution of the Beta Catenin antibody to be determined by the researcher.ImmunogenA partial human recombinant protein was used as the immunogen for the Beta Catenin antibody.StorageStore the Beta Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).Related Products1. View all Beta Catenin antibodies

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