首页 > NSJ Bio > NSJ Bio/BRCA1 Antibody [clone BRCA1/1472] (V3239)/20 ug/V3239-20UG

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NSJ Bio/BRCA1 Antibody [clone BRCA1/1472] (V3239)/20 ug/V3239-20UG

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V3239-20UG

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NSJ Bio

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DescriptionBRCA1 (Breast cancer type 1 susceptibility protein) is a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.Application NotesOptimal dilution of the BRCA1 antibody should be determined by the researcher.ImmunogenAmino acids 445-620 were used as the immunogen for the BRCA1 antibody.StorageStore the BRCA1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).Related Products1. View all BRCA1 antibodies

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