首页 > NSJ Bio > NSJ/E-Cadherin Antibody [clone CDH1/1121] (V3045)/V3045-20UG/ 20 ug

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NSJ/E-Cadherin Antibody [clone CDH1/1121] (V3045)/V3045-20UG/ 20 ug

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V3045-20UG

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NSJ Bio

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Formulation:0.2mg/mlin1XPBSwith0.1mg/mlBSA(USsourced)and0.05%sodiumazideData:Formulation:0.2mg/mlin1XPBSwith0.1mg/mlBSA(USsourced)and0.05%sodiumazideData:AvailABIlity1-3businessdaysSpeciesReactivityHumanandMouse.NotsuitableforRatsampletesting.Otherspeciesnotknown.FormatPurifiedClonalityMonoclonal(mouseorigin)IsotypeMouseIgG1,kappaCloneNameCDH1/1121PurityProteinGaffinitychromatographyUniProtP12830LocalizationCytoplasmic,membranousApplicationsFlowCytometry:0.5-1ug/millioncellsin0.1mlImmunofluorescence:0.5-1ug/mlWesternblot:0.5-1ug/mlImmunohistochemistry(FFPE):0.5-1ug/mlfor30minatRTPredilutedIHConlyformat:incubatefor30minatRT(1)LimitationsThisE-Cadherinantibodyisavailableforresearchuseonly.Description:Recognizesaproteinof80-120kDa,identifiedasE-cadherin/CDH1.CadherinscompriseafamilyofCa2+-dependentadhesionmoleculesthatfunctiontomediatecell-cellbindingcriticaltothemaintenanceoftissuestructureandmorphogenesis.Theclassicalcadherins,E-,N-andP-cadherin,consistoflargeextracellulardomainscharacterizedbyaseriesoffivehomologousNH2terminalrepeats.Therelativelyshortintracellulardomainsinteractwithavarietyofcytoplasmicproteins,suchasb-catenin,toregulatecadherinfunction.E-cadherinplaysanimportantroleinepithelialcelladhesion.AdecreasedexpressionofE-cadherinisassociatedwithmetastaticpotentialandpoorprognosisinbreastcancer,prostateandesophagealcancer.Incombinationwithp120Catenin,itisusefulforthedifferentiationbetweenductal(E-cadherin+)andlobular(E-cadherin-)breastcarcinomas.Itmayalsohelpindiagnosisofmesothelioma.Immunogen:Arecombinantfragment(119aminoacidresiduesaroundaa400-500)fromthehumanproteinwasusedastheimmunogenfortheE-Cadherinantibody.Storage:StoretheE-Cadherinantibodyat2-8oC(withazide)oraliquotandstoreat-20oCorcolder(withoutazide).

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