首页 > NSJ Bio > NSJ Bio/FOXO3A Antibody (R31609)/100 ug/R31609

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NSJ Bio/FOXO3A Antibody (R31609)/100 ug/R31609

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R31609

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DescriptionForkhead box O3, also known as FKHRL1 or FOXO3A, is a human protein encoded by the FOXO3 gene. FOXO3A belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. It is mapped to 6q21. This protein likely functions as a trigger for apoptosis through upregulation of genes necessary for cell death, such as Bim and PUMA, or downregulation of anti-apoptotic proteins such as FLIP. In mammals FOXO3A regulates the resistance of cells to stress by inducing DNA repair and thereby may also affect organismal life span. In addition, it is thought that FOXO3A is also involved in protection from oxidative stress by upregulating antioxidants such as catalase and MnSOD.Application NotesThe stated application concentrations are suggested starting amounts.Titration of the FOXO3A antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenHuman partial recombinant protein (AA 471-673) was used as the immunogen for this FOXO3A antibody.StorageAfter reconstitution, the FOXO3A antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing. Related Products1. View all FOXO3A antibodies

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