首页 > NSJ Bio > NSJ Bio/HDAC6 Antibody (R30680)/100 ug/R30680

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NSJ Bio/HDAC6 Antibody (R30680)/100 ug/R30680

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R30680

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DescriptionHistone deacetylase 6 is a member belsongs to clas II of the histone deacetylase/acuc/apha family of proteins and is an enzyme that in humans is encoded by the HDAC6 gene.It contains an internal duplication of two catalytic domains which appear to function independently of each other. The protein possesses histone deacetylase activity and represses transcription. HDAC6 functions as a tubulin deacetylase and it is localized exclusively in the cytoplasm, where it associates with microtubules and localizes with the microtubule motor complex. It can bind both polyubiquitinated misfolded proteins and dynein motors, thereby recruiting misfolded protein cargo to dynein motors for transport to aggresomes. Furthermore, expression of HDAC6 was sufficient to rescue degeneration associated with UPS dysfunction in vivo in an autophagy-dependent manner. HDAC6 is a central component of the stress response that regulates SG formation and potentially contributes to control of RNA metabolism and translation.Application NotesThe stated application concentrations are suggested starting amounts.Titration of the HDAC6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenAmino acids 1195-1209 (LLDVKNIAHQNKFGE-human) were used as the immunogen for this HDAC6 antibody.StorageAfter reconstitution, the HDAC6 antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing.Related Products1. View all HDAC antibodies2. View all HDAC6 antibodies

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