首页 > NSJ Bio > NSJ Bio/HLA-A Antibody (MHC I) [clone 108-2C5] (V2571)/100 ug/V2571-100UG

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NSJ Bio/HLA-A Antibody (MHC I) [clone 108-2C5] (V2571)/100 ug/V2571-100UG

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V2571-100UG

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DescriptionHLA-A, with HLA-B and HLA-C, belongs to major histocompatibility complex (MHC) class I antigens and expresses constitutively on all nucleated cells. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation. This mAb is useful for HLA molecular typing of peripheral blood leukocytes as well as a large number of leukemic cell lines. It reacts with an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, -A28, -A29, -A30, -A31 and Aw33). Its epitope maps between aa65-to-aa80 of the alpha1 domain of the HLA-A. This mAb recognizes an intralocus determinant present on a limited number of HLA-A locus-encoded gene products (HLA-A2, -A3, A28, -A29, -A30, -A31 and -Aw33). Furthermore, by testing its reactivity with HLA-A2 natural variants and mutants, the importance of amino acid residues 79 and/or 80 of the alpha1 domain was demonstrated in the formation of an intralocus HLA-A determinant.Application NotesOptimal dilution of the HLA-A antibody should be determined by the researcher.ImmunogenNormal human peripheral blood lymphocytes were used as the immunogen for the HLA-A antibody.StorageStore the HLA-A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide). Citations (7) Related Products1. View all HLA-A antibodies

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