首页 > NSJ Bio > NSJ Bio/PERK Antibody (F50992)/0.4 ml/F50992-0.4ML

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NSJ Bio/PERK Antibody (F50992)/0.4 ml/F50992-0.4ML

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F50992-0.4ML

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NSJ Bio

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DescriptionPERK, a member of the GCN2 subfamily of Ser/Thr protein kinases, phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It likely serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1 Perturbation in protein folding in the endoplasmic reticulum (ER) promotes reversible dissociation from HSPA5/BIP and oligomerization, resulting in transautophosphorylation and kinase activity induction Expression of this Type I membrane protein is ubiquitous, with highest levels seen in secretory tissues. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.Application NotesTitration of the PERK antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenA portion of amino acids 148-175 from the human protein was used as the immunogen for this PERK antibody.StorageAliquot the PERK antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles. Related Products1. View all PERK antibodies

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