首页 > NSJ Bio > NSJ Bio/PKC beta 2 Antibody / PRKCB2 (F40137)/0.08 ml/F40137-0.08ML

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NSJ Bio/PKC beta 2 Antibody / PRKCB2 (F40137)/0.08 ml/F40137-0.08ML

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F40137-0.08ML

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NSJ Bio

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DescriptionProtein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. PKC beta is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. Isoform 1 uses an alternate exon at the 3" end compared to isoform 2, which includes a part of the coding region. The resulting isoform 1 has a distinct and shorter C-terminus, as compared to isoform 2.Application NotesTitration of the PKC beta 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenA portion of amino acids 642-673 from the human protein was used as the immunogen for this PKC beta 2 antibody.StorageAliquot the PKC beta 2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles. Related Products1. View all PKC beta 2 antibodies

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