首页 > NSJ Bio > NSJ Bio/PLAU Antibody / Urokinase (RQ4217)/100 ug/RQ4217

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NSJ Bio/PLAU Antibody / Urokinase (RQ4217)/100 ug/RQ4217

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RQ4217

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DescriptionUrokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer"s disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.Application NotesOptimal dilution of the PLAU antibody should be determined by the researcher.ImmunogenA recombinant human protein corresponding to amino acids I179-L431 was used as the immunogen for the PLAU antibody.StorageAfter reconstitution, the PLAU antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. Related Products1. View all PLAU antibodies

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