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NSJ Bio/Prolactin Receptor Antibody (R31199)/100 ug/R31199

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DescriptionPRLR (Prolactin Receptor) is a cytokine receptor. By somatic cell hybrid analysis and by in situ hybridization, Arden et al. (1989, 1990) demonstrated that the gene resides in the same chromosomal region as the growth hormone receptor (GHR) gene, which has been mapped to 5p13-p12. Cunningham et al. (1990) demonstrated that zinc greatly increases the affinity of GH for the extracellular binding domain of PRLR, although it is not required for binding of GH to GHR or for binding of prolactin to the prolactin receptor. By mutational analysis, they showed that a cluster of 3 residues(histidine-18, histidine-21, and glutamic acid-174) in GH and histidine-188 in PRLR (conserved in all PRLRs but not GHRs) are likely zinc-ion ligands.Application NotesThe stated application concentrations are suggested starting amounts.Titration of the Prolactin Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenAn amino acid sequence from the C-terminus of mouse Prolactin Receptor (QLGRLDYLDPTCFMH) was used as the immunogen for this Prolactin Receptor antibody (100% rat homology).StorageAfter reconstitution, the Prolactin Receptor antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing. References (1) Citations (2) Related Products1. View all Prolactin Receptor antibodies

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