首页 > NSJ Bio > NSJ Bioreagents/ROCK2 Antibody (R30344)/100 ug/R30344

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NSJ Bioreagents/ROCK2 Antibody (R30344)/100 ug/R30344

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R30344

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DescriptionRho-associated kinase(ROCK), including the ROCK-I and ROCK-II isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. Serine/threonine kinase ROCK II/Rho kinase, which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. Sequencing analysis has shown that human ROCK II contains 1388 amino acid residues with a calculated molecular mass of approximately 161 kDa. Fluorescence in situ hybridization analysis showed that the human ROCK II gene is located on chromosome 2p24. Thumkeo et al.(2003) concluded that ROCK-II is essential in inhibiting blood coagulation and maintaining blood flow in the endothelium-free labyrinth layer and that loss of ROCK-II leads to thrombus formation, placental dysfunction, intrauterine growth retardation, and fetal death.Application NotesThe stated application concentrations are suggested starting amounts.Titration of the ROCK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenAn amino acid sequence from the N-terminus of human ROCK2 (RDPRSPINVESLLDGLN) was used as the immunogen for this ROCK2 antibody (100% homologous in human, mouse and rat).StorageAfter reconstitution, the ROCK2 antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing. Related Products1. View all ROCK2 antibodies

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