首页 > NSJ Bio > NSJ Bio/SSTR2 Antibody / Somatostatin Receptor 2 (R30779)/100 ug/R30779

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NSJ Bio/SSTR2 Antibody / Somatostatin Receptor 2 (R30779)/100 ug/R30779

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R30779

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DescriptionSomatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene. Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. Stable transfection of human pancreatic cells, which do not endogenously express SSTR2, inhibits cell proliferation, tumorigenicity, and metastasis. These effects occur as a consequence of an autocrine SSTR2-dependent loop, whereby SSTR2 induces expression of its own ligand, somatostatin. mRNA was variably expressed in all neuroblastoma tumors with a relevant reduction in the more advanced stage.Application NotesThe stated application concentrations are suggested starting amounts.Titration of the SSTR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.ImmunogenAn amino acid sequence from the middle region of human Somatostatin Receptor 2 (RSNQWGRSSCTINWP) was used as the immunogen for this SSTR2 antibody (100% homologous in human, mouse and rat).StorageAfter reconstitution, the SSTR2 antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing. Related Products1. View all SSTR2 antibodies

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