Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI waterData: Availability 1-3 business days Species Reactivity Human Format Antigen affinity purified Clonality Polyclonal (rabbit origin) Isotype Rabbit IgG Purity Antigen affinity Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide UniProt Q8NER1 Gene ID 7442 Applications Western blot : 0.5-1ug/mlIHC (FFPE) : 0.5-1ug/ml Limitations This TRPV1 antibody is available for research use only. Description:The transient receptor potential cation channel, subfamily V, member 1, also known as the capsaicin receptor is a protein which in humans is encoded by the TRPV1 gene. TRPV1 (also called Vanilloid receptor type 1 or VR1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. In addition to expression in primary afferents, it is also expressed in the CNS. Cui M et al. (2006) demonstrate that TRPV1 receptors in the CNS play an important role in pain mediated by central sensitization. And the significant CNS penetration is necessary for a TRPV1 antagonist to produce broad-spectrum analgesia. And it also participates in normal bladder function and is essential for normal mechanically evoked purinergic signaling by the urothelium.Application Notes:The stated application concentrations are suggested starting amounts. Titration of the TRPV1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.Immunogen:Human partial recombinant protein (AA 473-839) was used as the immunogen for this TRPV1 antibody.Storage:After reconstitution, the TRPV1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.