Adipogen/DLK1 (mouse):Fc (human) (rec.)/AG-40A-0107Y-3010/3 x 10 µg-蚂蚁淘生物

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Protein Delta Homolog 1; Fetal Antigen 1; Preadipocyte Factor 1; Pref-1; FA1

Protein

HEK 293 cells

Signal peptide and extracellular domain of mouse DLK1 (aa 1-305) are fused at the C-terminus to the Fc portion of human IgG1.

Mouse

Inhibits adipogenesis of 3T3L-1 cells. Induces Sox-9 in 3T3L-1 cells.

~75kDa (SDS-PAGE)

≥95% (SDS-PAGE)

0.1mg/ml after reconstitution.

Reconstitute with 100μl sterile water.

Lyophilized. Contains PBS + 0.02% CHAPS.

UniProt link Q09163: DLK (mouse)

BLUE ICE

+4°C

-20°C

After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.PBS containing at least 0.1% BSA should be used for further dilutions.

Stable for at least 6 months after receipt when stored at -20°C.

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The transmembrane and secreted protein delta-like 1 homolog (DLK1; Protein delta homolog 1; Preadipocyte factor 1; Pref-1) belongs to the EGF-like family. It can be cleaved by a tumor necrosis factor-α converting enzyme (TACE) to release a soluble form. DLK1 plays important roles in regulating cell differentiation such as adipogenesis and osteogenesis. Membrane-bound DLK1 promotes hypertrophic myotube formation, whereas soluble DLK1 inhibits myotube formation. The soluble form of DLK1 inhibits preadipocyte differentiation, while membrane DLK1 represses preadipocyte proliferation. DLK1 is also associated with tumor invasion.

Product References

Genes with physiological roles in callipyge muscle hypertrophy: H. Yu; Purde University Diss. Paper 10 (2013)

Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells: M. Rhee, et al.; Sci. Rep. 6, 23960 (2016)

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