Product | WWOX3 Antibody |
Description | Affinity Purified Oxidoreductase Antibody |
Verified Applications | ELISA, IHC, IP, WB |
Host | Rabbit |
Species Cross Reactivity | Human, Monkey, Rat |
Immunogen | Synthetic peptide taken within amino acid region 250-300 on human WWOXdelta5-8 protein. |
Accession # | GenBank: AAA21465.1 |
Physical Properties | |
Quantity | 100 µg |
Volume | 200 µl |
Concentration | 0.5-0.75 µg/µl in antibody stabilization buffer |
Form | Affinity Purified |
Clonality | Polyclonal |
Storage | -20⁰C for long term storage |
Application Protocol | |
DB | 1:10,000-1:100,000 |
ELISA | 1:10,000-1:100,000 |
| Immunohistochemistry | 1:50-1:150 |
Immunoprecipitation | 1:200 |
Western Blot | 1:500 |
Protein | |
Uniprot # | Q9NZC7 |
Overview | Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. |
Molecular Function | Coenzyme binding; protein dimerization activity; cofactor binding; |
Subcellular Location | Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus |
Expression | Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines. |
Structure | Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. Interacts with TNK2. Interacts with TMEM207. |
Alternative Nomenclature | D16S432E antibody FOR antibody FRA16D antibody Fragile site FRA16D oxidoreductase antibody HHCMA56 antibody PRO0128 antibody SCAR12 antibody SDR41C1 antibody short chain dehydrogenase/reductase family 41C member 1 antibody WW domain-containing oxidoreductase antibody wwox antibody WWOX_HUMAN antibody |
Protein information supplied by UniProt
