Product | FOLR1 Antibody |
Description | Affinity Purified Folate receptor Alpha Antibody |
Verified Applications | ELISA, IHC, IP, WB |
Host | Rabbit |
Species Cross Reactivity | Mouse, Rat |
Immunogen | Synthetic peptide taken within amino acid region 200-250 on mouse Folate receptor alpha protein. |
Physical Properties | |
Quantity | 100 µg |
Volume | 200 µl |
Concentration | 0.5 µg/µl in antibody stabilization buffer |
Immunoglobulin | IgG |
Form | Affinity Purified |
Purification Method | Immobilized antigen affinity chromatography |
Clonality | Polyclonal |
Storage | -20⁰C for long term storage |
Application Protocol | |
ELISA | 1:50,000 |
| Immunohistochemistry | 1:50-1:150 |
Immunoprecipitation | 1:200 |
Western Blot | 1:500 |
Protein | |
Uniprot # | P35846 |
Overview | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption. |
Molecular Function | Receptor |
Subcellular Location | Cell membrane, Cytoplasmic vesicle, Endosome, Membrane, Secreted |
Expression | Detected in kidney proximal tubules. |
Structure | Belongs to the folate receptor family. |
Alternative Nomenclature | adult antibodyAdult folate binding protein antibody FBP antibodyFolate Receptor 1 Adult antibodyFolate receptor 1 antibody Folate receptor alpha antibodyFolate receptor antibodyFOLR antibodyFOLR1 antibodyFR alpha antibodyKB cells FBP antibodyMOV18 antibodyOvarian cancer associated antigen antibodyOvarian tumor associated antigen MOv18 antibody |
Protein information supplied by UniProt
