General Information

Product

IKAP Antibody

Description

Affinity Purified IkappaB kinase complex-associated protein Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse

Immunogen

Recombinant IkappaB kinase complex-associated protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q7TT37

Overview

May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. Involved in neurogenesis (PubMed:19185337). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337).

Molecular Function

Phosphorylase kinase regulator activity

Subcellular Location

Cytoplasm, Nucleus

Expression

Widely expressed with highest levels in brain.

Alternative Nomenclature

DYS antibodyDysautonomia (Riley Day syndrome hereditary sensory autonomic neuropathy type III) antibodyElongator complex protein 1 antibodyELP1 antibodyFD antibodyIKAP antibodyIkappaB kinase complex associated protein antibodyikbkap antibodyIKI3 antibodyIKK complex associated protein antibodyInhibitor of kappa light polypeptide gene enhancer in B cells kinase complex associated protein antibodyp150 antibodyTOT1 antibody