PEGylated HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Liposomes with Ammonium Gradient (100nm)

HSPC/CHOL/mPEG-DSPE liposomes with ammonium gradient is the formulators choice in pharmaceutical/biotech industry for both formulation feasibility studies and liposomal product development, because HSPC is essentially equivalent to DSPC (HSPC containsabout 85 % DSPC15% DPPC). The main advantages for using HSPC are its lower cost and availability of GMP quality raw materials. HSPC material used at FormuMax is from one of the world’s premier lipid vendors.

A drug loaidng battery of 250 mM ammonium sulfate is typically used, howeverhigher concentrations ofammonium sulfate is also ues to achieve increased drug loading capacity and drugretention.

Specifications

Product code: F20204A

Lipid composition: HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol)

Mean particle size: 100 nm (95 - 120 nm)

Lipid concentration: 60 mM(60 - 65 mM)

Hydration buffer (loading battery):250 mM ammonium sulfate

External solution:10% sucrose, 20mM sodium PO4, pH 6.5 ± 0.2

Shelf-life:6 months

Storage:2-8°C, do not freeze

HSPC: hydrogenated phosphatidylcholine (Soy)

CHOL: cholesterol

mPEG2000-DSPE: 18:0 PEG2000 PE:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)