Description:

Type IV Collagenase, 72-kD, is officially designated matrix metalloproteinase-2(MMP2). It is also known as gelatinase, 72-kD. MMP-2 plays an essential role in angiogenesis and arteriogenesis, two processes critical to restoration of tissue perfusion after ischemia. MMP-2 expression is increased in tissue ischemia, but the responsible mechanisms remain unknown. Matrix metalloproteinases(MMPs) catalyze extracellular matrix degradation. Control of their activity is a promising target for therapy of diseases characterized by abnormal connective tissue turnover. MMPs are expressed as latent proenzymes that are activated by proteolytic cleavage that triggers a conformational change in the propeptide(cysteine switch). The structure of proMMP-2 reveals how the propeptide shields the catalytic cleft and that the cysteine switch may operate through cleavage of loops essential for propeptide stability. The gene is localized to 16q21 using somatic cell hybrids and in situ hybridization. The standard product used in this kit is recombinant human MMP-2, consisting of 631 amino acids with the molecular mass of 71KDa. The detected MMP-2 includes zymogen and active enzyme.

Additional Information:

Name Related Product Names Short Description Immunogen Standard Range Sample Type Specimen/Volumes Swiss Prot Number Concentration Applications GI Number Stability Reactivity Kit Size Storage Intended Use

Human MMP-2 ELISA Kit

72 kDa gelatinase|72 kDa type IV collagenase|CLG 4|CLG 4A|CLG4|CLG4A|Collagenase type IV A|EC 3.4.24.24|Gelatinase A|Gelatinase alpha|Gelatinase neutrophil|Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)|

Sandwich ELISA kit of Quantitative Detection for Human MMP-2

NSO, A30-C660

156pg/ml-10,000pg/ml. Test has a sensitivity of

This kit is used for quantitative detection of human MMP-2 in cell culture supernates, serum and plasma(heparin).

Refer to Manual

P08253

Lot Specific

ELISA

4313

Four months at 4C and eight months at -20C.

Reactive to Human. There is no detectable cross-reactivity with other relevant proteins.

1x96 well plate

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Research Use Only