Hycult Biotech/TIM-4, Mouse, mAb Kat5-18/HM1111/100 µg
Description: TIM-4, Mouse, mAb Kat5-18
The monoclonal antibody Kat5-18 recognizes T-cell immunoglobulin and mucin domain containing molecule (TIMD-4, also called TIM-4). TIMD-4 is a type I transmembrane protein belonging to the immunoglobulin superfamily, containing one Ig-like V-type (immunoglobulin-like) domain. TIMD-4 is expressed in Mac1+ cells in spleen, lymph nodes and fetal liver. TIMD-4 binds apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. TIMD-4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIMD-4 is involved in regulating T-cell proliferation and lymphotoxin signaling. TIMD-4 and TIMD-1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and are also involved in intracellular signaling in which exosomes are involved. The monoclonal antibody Kat5-18 blocks the engulfment of apoptotic cells by thymic macrophages.
Specifications:
Catalog number HM1111 |
Product type Monoclonal antibodies |
Quantity 100 µg |
Formulation 1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine serum albumin. |
Application Flow cytometry, Functional studies, Immuno assays, Immuno fluorescence |
Use For flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in users experimental setting. |
Immunogen Mouse peritoneal cells |
Isotype Armenian hamster IgG |
Species Mouse |
Alias TIMD4, TIM-4, T-cell immunoglobulin and mucin domain containing molecule |
References Miyanishi, M et al; Identification of Tim4 as a phosphatidylserine receptor. Nature 2007, 450: 435 |
Storage and stability Product should be stored at 4°C. Under recommended storage conditions, product is stable for one year. |
Precautions For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product. |
Disease Autoimmunity, Tumor immunology |